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SGLT2与糖尿病肾病
$47.16
SGLT(钠-葡萄糖共转运体)蛋白在肾小管重吸收葡萄糖的生理特性和SGLT抑制剂根皮苷的发现,共同奠定了具有划时代意义的新型降糖药物SGLT2抑制剂的开发和应用。《SGLT2与糖尿病肾病》综合国内外研究成果,在介绍SGLT的发现历程及肾脏重吸收葡萄糖的生物学基础上,系统阐述了SGLT2抑制剂在调节肾功能、血压和代谢中的作用,并总结既往临床试验中SGLT2抑制剂的降糖疗效和心肾获益,解析可能的保护机制。《SGLT2与糖尿病肾病》内...
SGLT(钠-葡萄糖共转运体)蛋白在肾小管重吸收葡萄糖的生理特性和SGLT抑制剂根皮苷的发现,共同奠定了具有划时代意义的新型降糖药物SGLT2抑制剂的开发和应用。《SGLT2与糖尿病肾病》综合国内外研究成果,在介绍SGLT的发现历程及肾脏重吸收葡萄糖的生物学基础上,系统阐述了SGLT2抑制剂在调节肾功能、血压和代谢中的作用,并总结既往临床试验中SGLT2抑制剂的降糖疗效和心肾获益,解析可能的保护机制。《SGLT2与糖尿病肾病》内容精练、翔实,有助于从事相关基础和临床工作的医师和研究人员深入理解和掌握SGLT2基本的病理生理学及其在肾脏疾病中的意义。
目录章 SGLT的发现历程 1节 苹果树皮的启发 1第二节 肾脏葡萄糖转运体的发现 1第三节 靶向肾脏葡萄糖转运的由来 2第四节 靶向肠道葡萄糖转运的可行性 4第五节 SGLT2抑制剂的发展 6第二章 肾脏重吸收葡萄糖的基本生物学 11节 肾脏中的葡萄糖转运蛋白 11第二节 葡萄糖重吸收的生理机制 12第三节 肾脏葡萄糖转运体的分布和功能 13第四节 葡萄糖重吸收的抑制物 15第五节 SGLTs和GLUTs转运葡萄糖的分子机制 15第六节 SGLTs的调节和结构 17第七节 抑制葡萄糖重吸收的分子结构基础 17第八节 肾脏葡萄糖转运相关遗传性疾病 18第三章 SGLT2抑制剂与肾脏的水盐代谢 23节 肾脏水盐调节的病理生理 23第二节 SGLT2抑制剂的水盐调节功能 27第三节 SGLT2抑制剂对肾小球滤过率的影响 29第四节 SGLT2抑制剂对血压的影响 31第四章 SGLT2抑制剂与代谢 35节 SGLT2抑制剂与糖代谢 35第二节 SGLT2抑制剂与脂代谢 37第三节 SGLT2抑制剂对氨基酸代谢的作用 40第四节 SGLT2抑制剂对减重的作用 40第五节 SGLT2抑制剂与线粒体功能 41第五章 SGLT2抑制剂在2型糖尿病中的应用 47节 SGLT2抑制剂降糖证据链不断完善 47第二节 SGLT2抑制剂在2型糖尿病中的获益 48第三节 SGLT2抑制剂在2型糖尿病中的潜在风险 54第六章 SGLT2抑制剂的心血管保护作用 65节 糖尿病心血管并发症的流行病学和发生机制 65第二节 SGLT2抑制剂预防和治疗心血管疾病的作用机制 68第三节 SGLT2抑制剂预防和治疗心血管疾病的临床研究 74第七章 SGLT2抑制剂与慢性肾脏病 81节 SGLT2抑制剂改善糖尿病肾病的肾脏结局 81第二节 SGLT2抑制剂改善非糖尿病CKD患者的肾脏预后 83第三节 SGLT2抑制剂在非糖尿病CKD中可能的肾脏保护机制 87第八章 SGLT2抑制剂辅助治疗1型糖尿病 96节 SGLT2抑制剂对T1DM患者的治疗作用 97第二节 SGLT-2抑制剂在1型糖尿病患者治疗中存在的潜在风险 100第三节 SGLT-2抑制剂在1型糖尿病患者中的适用范围 102第九章 SGLT2 抑制剂的临床试验概览 107节 SGLT2抑制剂作为降糖药物 107第二节 SGLT2抑制剂在不同人群中的应用 109第三节 SGLT2抑制剂作为心脏保护药物 110第四节 SGLT2抑制剂作为肾脏保护药物 113第五节 器官保护机制 114第六节 药物安全性 115第十章 SGLT2抑制剂的应用前景 124
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