转移性肝癌外科治疗
转移性肝癌外科治疗
15种转移性肝癌外科治疗全貌
复旦大学附属肿瘤医院肝外科30余年经验总结
汤钊猷院士作序推荐
19位专家，30余年治验总结
内容简介
15种转移性肝癌外科治疗全貌
复旦大学附属肿瘤医院肝外科30余年经验总结
汤钊猷院士作序推荐
19位专家，30余年治验总结
本书系复旦大学附属肿瘤医院肝脏外科针对15种常见转移性肝癌的外科治疗经验总结，详细介绍各种肝转移癌的流行病学、分期、分型、手术治疗、化疗、放疗、靶向治疗、免疫治疗、预后、随访等内容，重点介绍外科新术式与其他局部治疗手段如射频毁损、分子靶向及免疫等综合治疗方法的科学有效联用、疗效评价等方面的新进展。
本书涉及的内容，不仅可以为肿瘤外科临床医务人员提供专业指导，也为肿瘤内科、介入科、放疗科等同行提供循证基础上的证据和操作建议，也可供国内各级医学院校相关专业师生参考。
王鲁，男，1968年10月生，主任医师、教授、博导，复旦大学附属肿瘤医院肝脏外科主任，国际腹腔镜肝脏外科学会（ILLS）创始会员，国际肝胆胰协会（IHPBA）会员，世界外科协会（ISS）会员，国际肝胆胰协会中国分会肝胆胰肿瘤诊疗协作组组长，国际肝胆胰协会中国分会肝血管瘤专委会副主任委员。兼任中国抗癌协会胆道胂瘤专委会副主任委员、中国医师协会结直肠癌肝转移专委会副主任委员、中国抗癌协会肿瘤转移专委会青委会副主任委员、上海市抗癌协会肝胆肿瘤综合治疗专委会主任委员、上海市中西医结合学会肿瘤微创专委会副主任委员、上海市抗癌协会肿瘤微创治疗专业委员会腔镜外科学组副组长等。先后主持五项国家自然基金（负责人），主持国家科技重大专项目“肝癌精准肝切除技术和微创化治疗精准技术研究”。参加国家重点基础研究规划项目（“973”）、国家“863” 项目、十五科技攻关项目，获上海市科技进步二等奖和中华医学科技二等奖各一项。以第一作者或通讯作者发表SCI论文30篇左右，单篇最高IF=11.71，总影响因子150分左右。
一、转移性肝癌发病率 ……………………………………… １
二、转移性肝癌的分子机制 ………………………………… ３
三、转移性肝癌分层及预后判断 …………………………… ５
第二章 结直肠癌肝转移……………………………………… １２
一、概述 …………………………………………………… １２
二、分型与分期 …………………………………………… １３
三、治疗推荐 ……………………………………………… １３
（一）手术治疗 ………………………………………… １３
（二）介入治疗 ………………………………………… １８
（三）全身化疗 ………………………………………… ２０
转移性肝癌的治疗，包括系统性化疗、免疫靶向治疗以及针对肝脏病灶的局部治疗，如手术治疗、射频消融、放射治疗等。外科切除在常见转移性肝癌中的治疗价值已得到越来越多研究的证实。截至目前，根治性手术切除已成为结直肠癌肝转移和神经内分泌瘤肝转移的最有效治疗途径。随着外科手术技术的进步如微创外科开展、加速康复外科普及，以及有效的全身治疗药物不断出现、个体化精准分子诊断的发展，转移性肝癌的外科治疗经历了理念不断更新和适应证逐渐扩大的过程。对于不可切除肠癌肝转移与神经内分泌肿瘤肝转移患者，肝移植的安全性和有效性也得到了初步证实。但是，当前满足手术切除指征的患者占比较少，术后复发风险高等问题也不容忽视，转移性肝癌的整体预后仍较差。未来，转移性肝癌的外科治疗模式将进一步优化，通过受益人群的早期识别、手术时机的准确选择，以及MDT模式的全程管理，将进一步向精准医疗和个体化治疗迈进。
在此背景下，编纂此书的想法提上了议事日程，我们组织了相关的专家与学者，在大家的共同努力下，经过一年多的反复修改与撰写，本书得以顺利编写完成。
Shipping Overview:
• Shipping: Standard Domestic Shipping within the United States charges USD 4.99. Standard International Shipping from United Kingdom and Germany to the United States charges 14.99.
• Order Processing: Please allow 1-2 business days for order processing and preparation before shipment.
• Domestic Shipping: Orders within the U.S. are shipped via USPS or FedEx, depending on the origin of the product. The average transit time is 3-7 business days.
• International Shipping: Currently, we only ship within the USA.
• Tracking Information: Every order is trackable. You will receive a tracking number once your order has been shipped. Products may be shipped from various global fulfillment centers.
Shipping Delays:
Please note that shipping times may vary due to factors beyond our control, such as weather conditions, natural disasters, or peak holiday periods. While we strive to ensure timely delivery, the exact arrival time cannot be guaranteed and is managed by the shipping carrier.
Shipping Options:
-
Standard Delivery: Most orders are shipped within 3-7 business days. Larger items may utilize LTL shipping for safe handling.
-
Handling Time: We handle shipments on business days (Monday - Friday), with a preparation time of 1-2 days.
-
Additional Charges: Some items require additional shipping charges due to their size, weight, or special handling. These charges are specified on the product pages and are not eligible for shipping discounts.
-
Exclusions: Gift cards, packaging, taxes, and prior purchases do not count toward the minimum purchase requirement for free shipping. This offer is valid only for shipments to U.S. addresses, including Puerto Rico.
Delivery Details:
-
Estimates: Standard shipping within the US typically takes 3-7 business days. These are estimates and not guarantees.
-
Shipping Restrictions: We ship to all 50 states, Washington, DC, U.S. territories, and APO/FPO/DPO addresses. Shipping options vary based on the delivery address.
-
Remote Areas: Shipments to remote areas may incur additional charges or require pickup from a nearby shipping partner’s location.
Shipping Confirmation:
You will receive a shipping confirmation email with a tracking number as soon as your order is dispatched. If you do not receive this email immediately, please be assured that your items will arrive within the estimated delivery window provided at checkout.
Order Modifications:
If you need to cancel or modify your order, please contact our customer support immediately.
Issues with Delivery:
If your order shows as delivered but you have not received it, please contact the shipping carrier directly to resolve the issue. For persistent problems, contact our customer service at cs@everymarket.com.
Customer Support:
Our team is available 24/7 to assist you with any questions or concerns regarding your order. We are committed to ensuring a smooth shopping experience.
Return & Refund Policy Overview
Please review our return and refund policies below to ensure a smooth transaction process.
Return Policy
-
Duration: You have 30 days from receiving your item to initiate a return.
-
Condition: Items must be unworn, unwashed, with original tags and packaging intact.
-
Shipping Costs: Customers are responsible for return shipping costs.
-
Packaging: Ensure returned items are well-packaged to avoid damage during transit.
-
Tracking: Use a trackable and insured shipping method as we are not liable for items lost or damaged on return.
-
Initiating a Return: Contact us at cs@everymarket.com to start your return. We will provide a return shipping label and instructions upon approval. Returns without prior approval will not be accepted.
How to Return
-
Method: Returns must be sent back by mail to the address provided in the return instructions.
Return Label
-
Defective Products: Return labels are provided for defective items.
-
Non-Defective Returns: Customers are responsible for obtaining their return shipping label.
Product Conditions for Return
-
Eligible Products: Returns are only accepted for items in new condition.
Nonreturnable Items
Certain items are not eligible for return:
-
Electronic devices after 30 days (e.g., computers, laptops, Kindles)
-
Gift cards, prepaid game cards
-
Perishable goods, live insects, some jewelry, some health and personal care items
-
Customized or personalized products
-
Items with special shipping restrictions
Refund Policy
-
Window: Eligible products may be returned within 30 days of delivery for a refund.
-
Refund Method: Refunds are processed to the original payment method or as store credit for items purchased with gift cards.
-
Processing Time: Refunds are processed within 3-5 business days after we receive the return; please allow additional time for shipping and bank processing.
Claims
Inspect your order upon arrival and report any defects, damages, or incorrect items immediately to allow us to address the issue. For claims, contact our support team with details of the issue.
Exchange Policy
For the quickest service, return your original item and place a new order for the desired product once your return is accepted.
Return Address
EveryMarket Customer Service 2101 E Terra Ln, O'Fallon, MO 63366
Customer Support
Available 24/7 for any questions or assistance needed:
-
Phone: +1 636-312-5925
-
Email: cs@everymarket.com
15种转移性肝癌外科治疗全貌
复旦大学附属肿瘤医院肝外科30余年经验总结
汤钊猷院士作序推荐
19位专家，30余年治验总结
本书系复旦大学附属肿瘤医院肝脏外科针对15种常见转移性肝癌的外科治疗经验总结，详细介绍各种肝转移癌的流行病学、分期、分型、手术治疗、化疗、放疗、靶向治疗、免疫治疗、预后、随访等内容，重点介绍外科新术式与其他局部治疗手段如射频毁损、分子靶向及免疫等综合治疗方法的科学有效联用、疗效评价等方面的新进展。
本书涉及的内容，不仅可以为肿瘤外科临床医务人员提供专业指导，也为肿瘤内科、介入科、放疗科等同行提供循证基础上的证据和操作建议，也可供国内各级医学院校相关专业师生参考。
王鲁，男，1968年10月生，主任医师、教授、博导，复旦大学附属肿瘤医院肝脏外科主任，国际腹腔镜肝脏外科学会（ILLS）创始会员，国际肝胆胰协会（IHPBA）会员，世界外科协会（ISS）会员，国际肝胆胰协会中国分会肝胆胰肿瘤诊疗协作组组长，国际肝胆胰协会中国分会肝血管瘤专委会副主任委员。兼任中国抗癌协会胆道胂瘤专委会副主任委员、中国医师协会结直肠癌肝转移专委会副主任委员、中国抗癌协会肿瘤转移专委会青委会副主任委员、上海市抗癌协会肝胆肿瘤综合治疗专委会主任委员、上海市中西医结合学会肿瘤微创专委会副主任委员、上海市抗癌协会肿瘤微创治疗专业委员会腔镜外科学组副组长等。先后主持五项国家自然基金（负责人），主持国家科技重大专项目“肝癌精准肝切除技术和微创化治疗精准技术研究”。参加国家重点基础研究规划项目（“973”）、国家“863” 项目、十五科技攻关项目，获上海市科技进步二等奖和中华医学科技二等奖各一项。以第一作者或通讯作者发表SCI论文30篇左右，单篇最高IF=11.71，总影响因子150分左右。
一、转移性肝癌发病率 ……………………………………… １
二、转移性肝癌的分子机制 ………………………………… ３
三、转移性肝癌分层及预后判断 …………………………… ５
第二章 结直肠癌肝转移……………………………………… １２
一、概述 …………………………………………………… １２
二、分型与分期 …………………………………………… １３
三、治疗推荐 ……………………………………………… １３
（一）手术治疗 ………………………………………… １３
（二）介入治疗 ………………………………………… １８
（三）全身化疗 ………………………………………… ２０
转移性肝癌的治疗，包括系统性化疗、免疫靶向治疗以及针对肝脏病灶的局部治疗，如手术治疗、射频消融、放射治疗等。外科切除在常见转移性肝癌中的治疗价值已得到越来越多研究的证实。截至目前，根治性手术切除已成为结直肠癌肝转移和神经内分泌瘤肝转移的最有效治疗途径。随着外科手术技术的进步如微创外科开展、加速康复外科普及，以及有效的全身治疗药物不断出现、个体化精准分子诊断的发展，转移性肝癌的外科治疗经历了理念不断更新和适应证逐渐扩大的过程。对于不可切除肠癌肝转移与神经内分泌肿瘤肝转移患者，肝移植的安全性和有效性也得到了初步证实。但是，当前满足手术切除指征的患者占比较少，术后复发风险高等问题也不容忽视，转移性肝癌的整体预后仍较差。未来，转移性肝癌的外科治疗模式将进一步优化，通过受益人群的早期识别、手术时机的准确选择，以及MDT模式的全程管理，将进一步向精准医疗和个体化治疗迈进。
在此背景下，编纂此书的想法提上了议事日程，我们组织了相关的专家与学者，在大家的共同努力下，经过一年多的反复修改与撰写，本书得以顺利编写完成。
Shipping Overview:
• Shipping: Standard Domestic Shipping within the United States charges USD 4.99. Standard International Shipping from United Kingdom and Germany to the United States charges 14.99.
• Order Processing: Please allow 1-2 business days for order processing and preparation before shipment.
• Domestic Shipping: Orders within the U.S. are shipped via USPS or FedEx, depending on the origin of the product. The average transit time is 3-7 business days.
• International Shipping: Currently, we only ship within the USA.
• Tracking Information: Every order is trackable. You will receive a tracking number once your order has been shipped. Products may be shipped from various global fulfillment centers.
Shipping Delays:
Please note that shipping times may vary due to factors beyond our control, such as weather conditions, natural disasters, or peak holiday periods. While we strive to ensure timely delivery, the exact arrival time cannot be guaranteed and is managed by the shipping carrier.
Shipping Options:
-
Standard Delivery: Most orders are shipped within 3-7 business days. Larger items may utilize LTL shipping for safe handling.
-
Handling Time: We handle shipments on business days (Monday - Friday), with a preparation time of 1-2 days.
-
Additional Charges: Some items require additional shipping charges due to their size, weight, or special handling. These charges are specified on the product pages and are not eligible for shipping discounts.
-
Exclusions: Gift cards, packaging, taxes, and prior purchases do not count toward the minimum purchase requirement for free shipping. This offer is valid only for shipments to U.S. addresses, including Puerto Rico.
Delivery Details:
-
Estimates: Standard shipping within the US typically takes 3-7 business days. These are estimates and not guarantees.
-
Shipping Restrictions: We ship to all 50 states, Washington, DC, U.S. territories, and APO/FPO/DPO addresses. Shipping options vary based on the delivery address.
-
Remote Areas: Shipments to remote areas may incur additional charges or require pickup from a nearby shipping partner’s location.
Shipping Confirmation:
You will receive a shipping confirmation email with a tracking number as soon as your order is dispatched. If you do not receive this email immediately, please be assured that your items will arrive within the estimated delivery window provided at checkout.
Order Modifications:
If you need to cancel or modify your order, please contact our customer support immediately.
Issues with Delivery:
If your order shows as delivered but you have not received it, please contact the shipping carrier directly to resolve the issue. For persistent problems, contact our customer service at cs@everymarket.com.
Customer Support:
Our team is available 24/7 to assist you with any questions or concerns regarding your order. We are committed to ensuring a smooth shopping experience.
Return & Refund Policy Overview
Please review our return and refund policies below to ensure a smooth transaction process.
Return Policy
-
Duration: You have 30 days from receiving your item to initiate a return.
-
Condition: Items must be unworn, unwashed, with original tags and packaging intact.
-
Shipping Costs: Customers are responsible for return shipping costs.
-
Packaging: Ensure returned items are well-packaged to avoid damage during transit.
-
Tracking: Use a trackable and insured shipping method as we are not liable for items lost or damaged on return.
-
Initiating a Return: Contact us at cs@everymarket.com to start your return. We will provide a return shipping label and instructions upon approval. Returns without prior approval will not be accepted.
How to Return
-
Method: Returns must be sent back by mail to the address provided in the return instructions.
Return Label
-
Defective Products: Return labels are provided for defective items.
-
Non-Defective Returns: Customers are responsible for obtaining their return shipping label.
Product Conditions for Return
-
Eligible Products: Returns are only accepted for items in new condition.
Nonreturnable Items
Certain items are not eligible for return:
-
Electronic devices after 30 days (e.g., computers, laptops, Kindles)
-
Gift cards, prepaid game cards
-
Perishable goods, live insects, some jewelry, some health and personal care items
-
Customized or personalized products
-
Items with special shipping restrictions
Refund Policy
-
Window: Eligible products may be returned within 30 days of delivery for a refund.
-
Refund Method: Refunds are processed to the original payment method or as store credit for items purchased with gift cards.
-
Processing Time: Refunds are processed within 3-5 business days after we receive the return; please allow additional time for shipping and bank processing.
Claims
Inspect your order upon arrival and report any defects, damages, or incorrect items immediately to allow us to address the issue. For claims, contact our support team with details of the issue.
Exchange Policy
For the quickest service, return your original item and place a new order for the desired product once your return is accepted.
Return Address
EveryMarket Customer Service 2101 E Terra Ln, O'Fallon, MO 63366
Customer Support
Available 24/7 for any questions or assistance needed:
-
Phone: +1 636-312-5925
-
Email: cs@everymarket.com
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