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自身免疫性疾病与女性健康
$63.67
风湿病的著作并不少见,但关注自身免疫性疾病对女性健康及妊娠与妊娠结局影响的专著却很少见,本书堪称该领域一部里程碑式的专著。
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本书引进自 Springer 出版社,是一部重点向妇科及其他科室临床医生传达女性自身免疫性疾病知识的实用指南。全书共 26 章,系统回顾了各种自身免疫性疾病的治疗文献、疾病严重程度分级、对生育的影响,以及如何让患有该类疾病的患者做好妊娠准备等内容。
本书解决了目前文献中没有为该类疾病提供有效指导的问题,为临床医生提供了可实施的治疗方法及可能的替代方案。同时,本书还探讨了与女性自身免疫性疾病有关的重要问题,如狼疮性肾炎、血管炎、干燥综合征、抗磷脂综合征和系统性硬化症,以及这些疾病对未出生婴儿的潜在影响。本书可为从事相关专业的临床医生、风湿病学专家和妇科医生提供有价值的参考。
主审:徐沪济,教授,海军军医大学长征医院内科学教研室主任和风湿免疫科主任,清华大学医学院教授,清华 - 北大生命科学中心临床研究员。先后担任中华医学会风湿病学分会副主任委员,中国医师学会风湿免疫科分会副会长,解放军免疫学专业委员会副主任委员,上海市医学会风湿病专科分会主任委员,“国之名医·卓越建树”奖获得者,国家科技部“973 计划”首席科学家,军队“科技金星”奖获得者,风湿病顶J国际期刊 Annals of the Rheumatic Diseases编委,Frontiers in Immunology 和 Frontiers in Medicine 副主编,《中国内科年鉴》主编。
第 1 章 遗传因素在自身免疫性疾病中的作用一、概述二、自身免疫性疾病遗传基础的流行病学分析三、自身免疫性疾病的机制四、自身免疫与原发性免疫缺陷的重叠五、结论第 2 章 性别对自身免疫性疾病的影响一、概述二、类风湿关节炎三、系统性红斑狼疮四、系统性硬化症五、干燥综合征六、强直性脊柱炎七、银屑病关节炎八、结论第 3 章 系统性红斑狼疮与干燥综合征的性别偏倚一、系统性红斑狼疮二、干燥综合征三、系统性红斑狼疮和干燥综合征的性别偏倚四、系统性红斑狼疮和干燥综合征性别偏倚的相关因素五、结论第 4 章 妊娠中的自身抗体一、概述二、抗核抗体三、抗 Ro/La 抗体四、抗着丝点蛋白抗体五、抗甲状腺抗体六、抗凝血酶原抗体七、抗层粘连蛋白抗体八、抗滋养层抗体九、抗父系 B 淋巴细胞的母体抗体十、抗人类白细胞抗原抗体十一、妊娠期抗 IgA 抗体十二、抗酿酒酵母抗体十三、抗人血小板抗原 -1a 抗体十四、导致多发性肌炎的抗信号识别颗粒抗体和其对妊娠期的影响第 5 章 抗磷脂综合征的实验室检查一、抗磷脂综合征二、抗磷脂综合征的实验室检查三、治疗和预防四、结论第 6 章 自身免疫性疾病对生育功能及妊娠的影响一、类风湿关节炎患者的生育和妊娠二、系统性红斑狼疮患者的生育和妊娠三、系统性硬化症患者的生育和妊娠四、原发性干燥综合征患者的生育和妊娠五、血管炎患者的生育和妊娠六、混合性结缔组织病患者的生育和妊娠七、炎症性肌病患者的生育和妊娠八、高危妊娠的孕前咨询和管理第 7 章 妊娠期使用生物或小分子靶向抗风湿药物的Z新进展一、概述二、结论第 8 章 对自身免疫性疾病女性患者月经紊乱的管理一、概述及背景二、流行病学和病理生理学三、月经紊乱的管理第 9 章 生殖毒性药物治疗自身免疫性疾病女性的生育力保存一、致性腺毒性的风险和机制二、生育力保存的措施三、生育力保存技术的比较第 10 章 对自身免疫性疾病患者的备孕辅导及咨询一、系统性红斑狼疮二、类风湿关节炎三、系统性硬化症四、抗磷脂综合征五、结论第 11 章 妊娠对自身免疫性疾病的影响一、概述二、妊娠期间的免疫变化三、妊娠和风湿性疾病四、总结第 12 章 妊娠期红斑狼疮发作的处理一、比较红斑狼疮患者妊娠和正常妊娠二、 SLE 患者辅导及妊娠计划核对表三、不建议妊娠的情况四、妊娠期子痫前期与狼疮性肾炎的差异五、不良预后指标六、定义七、肾脏移植八、其他器官复发九、红斑狼疮妊娠和 HELLP 综合征十、血液学的复发十一、妊娠期急性脂肪肝十二、外周涂片:裂细胞十三、抗磷脂综合征十四、感染十五、模拟十六、糖皮质激素十七、Z新进展十八、关键信息第 13 章 狼疮性肾炎与妊娠管理一、狼疮性肾炎是否会影响生育二、妊娠对狼疮性肾炎的影响三、狼疮性肾炎对妊娠的影响四、结论第 14 章 系统性血管炎与妊娠管理一、概述二、妊娠期间免疫变化三、系统性血管炎对生育能力的影响四、产前和产前护理五、妊娠结局六、妊娠对系统性血管炎的影响及药物治疗七、结论第 15 章 抗磷脂综合征与妊娠管理一、概述二、妊娠期或妊娠前女性应何时进行 APLA 检测三、妊娠期抗磷脂综合征或 APLA 阳性的处理四、一些常见的病例场景五、各种问题讨论六、结论第 16 章 系统性硬化症与妊娠管理一、系统性硬化症的生育能力二、妊娠结局三、早产四、妊娠对系统性硬化症的影响五、妊娠的管理六、分娩管理七、结论第 17 章 对抗 Ro/La 抗体阳性孕妇的健康管理一、概述二、发病机制三、新生儿红斑狼疮的临床特点四、抗 Ro/La 抗体阳性母亲的分娩和围产期结局五、管理第 18 章 妊娠期干燥综合征的管理一、概述二、妊娠前的注意事项三、妊娠期间的考虑四、妊娠和分娩时需要考虑的其他因素五、关于生育率和 pSS 的思考第 19 章 自身免疫性疾病患者中孕产并发症的发病率与死亡率一、为何 SLE 发病率及死亡率Z高二、肾脏问题三、潜在间质性肺病和肺动脉高压(PAH)的风险四、孕妇的心脏也会受到影响五、妊娠、凝血功能和免疫异常六、大脑受累七、败血症的风险八、自身免疫性疾病的治疗与妊娠九、结论第 20 章 妊娠期抗风湿药物的使用一、概述二、抗炎和合成类缓解病情药物三、静脉注射免疫球蛋白四、生物制剂和小分子靶向药五、阿普司特六、慢性疼痛管理七、抗凝血药八、降压药九、PDE-5 抑制药十、双膦酸盐第 21 章 非甾体抗炎药对妊娠和哺乳期的影响一、概述二、妊娠期 NSAID 的应用三、哺乳期 NSAID 的使用四、结论第 22 章 新生儿心脏传导阻滞的处理一、概述二、免疫介导的 CCAVB三、CCAVB 的自然病程四、产前完全性心脏传导阻滞的心脏评估五、药物治疗六、β 受体激动药七、产后管理八、起搏器的选择九、关键点第 23 章 印度女性自身免疫性疾病患者数据汇编一、概述二、印度女性风湿病的流行病学特征三、系统性红斑狼疮四、抗磷脂综合征五、类风湿关节炎六、血管炎第 24 章 自身免疫性疾病与女性骨质疏松一、背景二、流行病学三、病理生理学四、危险因素五、骨质疏松和自身免疫性疾病六、糖皮质激素诱发的骨质疏松七、骨折风险评估工具八、管理九、结论第 25 章 自身免疫性疾病与女性更年期和激素替代疗法一、概述二、更年期与临床、激素和免疫学变化的关联三、卵巢早衰和自身免疫四、更年期和自身免疫性疾病五、结论第 26 章 纤维肌痛一、临床特征二、发病机制三、诊断四、评估 CWP 患者时的检查五、治疗六、非药物治疗七、纤维肌痛和妊娠
中文版序世纪交替的 20 年间,中国风湿免疫学的研究与时俱进、飞速发展,成为医学研究发展中不可或缺的一部分。风湿免疫学研究涵盖了此类疾病所涉及的各个领域,包括流行病学、免疫学机制、遗传学、伴发疾病、分类诊断及治疗策略、愈后及心理状态等,其中流行病学研究已充分显现出风湿免疫疾病的主要受累人群是女性,特别是系统性红斑狼疮、类风湿关节炎及干燥综合征等系统性风湿免疫疾病更为明显。虽然迄今尚未揭示性别差异的确切机制,但现有研究发现,疾病的发生可能与性激素、遗传及肠道宏基因等多种因素关系密切。而女性生理特征和社会角色决定了其在疾病分类诊断、治疗及管理决策中的特殊性,如妊娠期性激素改变可影响体内免疫平衡,进而触发某些自身免疫性疾病的活动或复发;病情活动的妊娠期患者,其治疗策略的选择受到诸多因素限制;控制疾病与维持妊娠的艰难选择等。此外,风湿免疫疾病常导致多器官受累,针对备孕期、妊娠期及哺乳期患者的用药,需要依托风湿免疫科、妇科、产科、生殖科及其他多学科团队的沟通合作。由于风湿免疫疾病对女性身心健康的特殊影响,如何切实有效地缓解或消除患者的病痛疾苦,是摆在广大医者面前重大且紧迫的课题。他山之石,可以攻玉。Women’s Health in Autoimmune Diseases 一书是为数不多的关注并论述风湿免疫疾病对女性健康、妊娠和妊娠结局等诸多方面影响及诊断治疗的专著。该书针对女性风湿疾病患者群,多维度、全方位深入探讨了其面临的治疗及管理策略,总结归纳了全新的研究成果与成功的治疗经验,可为风湿免疫研究人员、临床医生、有志投身风湿免疫学科的年轻学子提供参考与借鉴,是一部系统性的全新资料与教材。近年来,海军军医大学(原第二军医大学)长征医院风湿免疫科在徐沪济教授的带领下声誉鹊起,已成为国内外具有重要影响力的风湿免疫疾病临床和研究中心之一,科内的女医生们巾帼不让须眉,她们从女性自身的角度为女性患者着想,满怀医者的仁爱之心,用女医生特有的细腻坚韧精神,发挥人民军队团队拼搏的优良传统,牺牲了宝贵的休息时间,倾情翻译了本书。徐沪济教授以风湿免疫学科领军人的真知灼见和国际视野,对本书进行了严格精准的审核把关,为这部译著的完美呈现增色添彩。本书的翻译出版,填补了国内在此领域的空白,为提高广大女性患者健康、推动风湿免疫学科的诊治水平,贡献了一份力量。作为首届中国女医师协风湿免疫专业委员会的主任委员,为本书的出版点赞!是为序。北京大学人民医院 苏茵
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