儿科免疫系统疾病诊疗规范（第2版）
儿科免疫系统疾病诊疗规范（第2版）
本书为“儿科疾病诊疗规范丛书”其中一分册，由中华医学会儿科学分会免疫学组组织专家经过近1年时间的精心打磨而成。
本书囊括了临床常见的免疫系统疾病，将诊疗要点与国内外进展相结合，形成各疾病的诊疗规范；在对免疫系统疾病的概念、病因与发病机制、临床表现、诊断与鉴别诊断及治疗的描写中，注重诊疗思维的培养；每一章节末尾的诊疗流程图都是编者斟字酌句，潜心提炼的精华之笔，为广大儿科医生和儿童免疫科医生提供详尽、全面的参考。
本套丛书已经成为各级儿科从业人员日常学习和参考的案头工具书，为儿科学科发展起到积极的促进作用。
全书43万字，在上一版的基础上修订30%以上，共六章，包括儿童免疫学总论、原发性免疫缺陷病、继发性免疫缺陷病、儿童过敏性疾病、儿童风湿性疾病、免疫功能异常与疫苗接种。全书文字精炼、表达流畅、脉络清晰、内容经典、重点突出、理念先进，并有大量诊治流程图，为读者提供分析思路，是一本具备先进性、科学性和实用性的专业工具书。
赵晓东：中华医学会儿科学分会免疫学组前任组长
宋红梅：中华医学会儿科学分会免疫学组组长
第一节免疫系统/1
第二节免疫应答/2
第三节免疫应答失调与疾病/4
|第二章|原发性免疫缺陷病/9
第一节原发性免疫缺陷病概述/9
第二节原发性免疫缺陷病分类/14
第三节免疫功能评估/90
第四节原发性免疫缺陷疾病临床表现及早期识别/97
第五节重症联合免疫缺陷病/102
第六节湿疹、血小板减少伴免疫缺陷综合征/112
第七节DiGeorge综合征/118
第八节高IgE综合征/122
第九节X-连锁无丙种球蛋白血症/131
儿童免疫学涵盖的原发性免疫缺陷病（PID）、儿童过敏性疾病和儿童风湿性疾病，免疫系统功能异常是这几类疾病最重要的发病机制。儿童免疫系统发育特征决定了儿童时期的这几类疾病也具有鲜明的、不同于成人的疾病特点。可见，儿童免疫学涵盖的上述三类经典疾病其实同宗同源，具有深厚的内在联系。还值得强调的是，儿童免疫性疾病许多临床表型也与儿科学各亚学科（专业）密切相关。因此，儿科免疫性疾病的诊疗过程必须采取学科交叉的方法。
近10 年是儿童免疫学进入爆发式发展时期，免疫学发展速度非常迅猛，大量的基础和相关转化研究成果如雨后春笋般涌现。随着高通量测序技术的广泛应用，原发性免疫缺陷病致病基因增长到目前的400 多个，除经典免疫分子外，表观遗传、核酸和蛋白质稳态维持等一系列相关基因变异导致的原发性免疫缺陷病不断被发现。诸多免疫通路的运行规律以原发性免疫缺陷病病例为研究对象得以破解。众多小分子 / 大分子药物依托免疫靶点得以发明并应用于临床，多种原发性免疫缺陷病的基因治疗完成了临床试验。同样，儿童风湿病 / 过敏性疾病的理论研究和临床实践也在飞速发展，人们对感染过程的深入解析，阐明了感染本身的转归规律，也部分阐明了肿瘤发生的多种机制。
Shipping Overview:
• Shipping: Standard Domestic Shipping within the United States charges USD 4.99. Standard International Shipping from United Kingdom and Germany to the United States charges 14.99.
• Order Processing: Please allow 1-2 business days for order processing and preparation before shipment.
• Domestic Shipping: Orders within the U.S. are shipped via USPS or FedEx, depending on the origin of the product. The average transit time is 3-7 business days.
• International Shipping: Currently, we only ship within the USA.
• Tracking Information: Every order is trackable. You will receive a tracking number once your order has been shipped. Products may be shipped from various global fulfillment centers.
Shipping Delays:
Please note that shipping times may vary due to factors beyond our control, such as weather conditions, natural disasters, or peak holiday periods. While we strive to ensure timely delivery, the exact arrival time cannot be guaranteed and is managed by the shipping carrier.
Shipping Options:
-
Standard Delivery: Most orders are shipped within 3-7 business days. Larger items may utilize LTL shipping for safe handling.
-
Handling Time: We handle shipments on business days (Monday - Friday), with a preparation time of 1-2 days.
-
Additional Charges: Some items require additional shipping charges due to their size, weight, or special handling. These charges are specified on the product pages and are not eligible for shipping discounts.
-
Exclusions: Gift cards, packaging, taxes, and prior purchases do not count toward the minimum purchase requirement for free shipping. This offer is valid only for shipments to U.S. addresses, including Puerto Rico.
Delivery Details:
-
Estimates: Standard shipping within the US typically takes 3-7 business days. These are estimates and not guarantees.
-
Shipping Restrictions: We ship to all 50 states, Washington, DC, U.S. territories, and APO/FPO/DPO addresses. Shipping options vary based on the delivery address.
-
Remote Areas: Shipments to remote areas may incur additional charges or require pickup from a nearby shipping partner’s location.
Shipping Confirmation:
You will receive a shipping confirmation email with a tracking number as soon as your order is dispatched. If you do not receive this email immediately, please be assured that your items will arrive within the estimated delivery window provided at checkout.
Order Modifications:
If you need to cancel or modify your order, please contact our customer support immediately.
Issues with Delivery:
If your order shows as delivered but you have not received it, please contact the shipping carrier directly to resolve the issue. For persistent problems, contact our customer service at cs@everymarket.com.
Customer Support:
Our team is available 24/7 to assist you with any questions or concerns regarding your order. We are committed to ensuring a smooth shopping experience.
Return & Refund Policy Overview
Please review our return and refund policies below to ensure a smooth transaction process.
Return Policy
-
Duration: You have 30 days from receiving your item to initiate a return.
-
Condition: Items must be unworn, unwashed, with original tags and packaging intact.
-
Shipping Costs: Customers are responsible for return shipping costs.
-
Packaging: Ensure returned items are well-packaged to avoid damage during transit.
-
Tracking: Use a trackable and insured shipping method as we are not liable for items lost or damaged on return.
-
Initiating a Return: Contact us at cs@everymarket.com to start your return. We will provide a return shipping label and instructions upon approval. Returns without prior approval will not be accepted.
How to Return
-
Method: Returns must be sent back by mail to the address provided in the return instructions.
Return Label
-
Defective Products: Return labels are provided for defective items.
-
Non-Defective Returns: Customers are responsible for obtaining their return shipping label.
Product Conditions for Return
-
Eligible Products: Returns are only accepted for items in new condition.
Nonreturnable Items
Certain items are not eligible for return:
-
Electronic devices after 30 days (e.g., computers, laptops, Kindles)
-
Gift cards, prepaid game cards
-
Perishable goods, live insects, some jewelry, some health and personal care items
-
Customized or personalized products
-
Items with special shipping restrictions
Refund Policy
-
Window: Eligible products may be returned within 30 days of delivery for a refund.
-
Refund Method: Refunds are processed to the original payment method or as store credit for items purchased with gift cards.
-
Processing Time: Refunds are processed within 3-5 business days after we receive the return; please allow additional time for shipping and bank processing.
Claims
Inspect your order upon arrival and report any defects, damages, or incorrect items immediately to allow us to address the issue. For claims, contact our support team with details of the issue.
Exchange Policy
For the quickest service, return your original item and place a new order for the desired product once your return is accepted.
Return Address
EveryMarket Customer Service 2101 E Terra Ln, O'Fallon, MO 63366
Customer Support
Available 24/7 for any questions or assistance needed:
-
Phone: +1 636-312-5925
-
Email: cs@everymarket.com
本书为“儿科疾病诊疗规范丛书”其中一分册，由中华医学会儿科学分会免疫学组组织专家经过近1年时间的精心打磨而成。
本书囊括了临床常见的免疫系统疾病，将诊疗要点与国内外进展相结合，形成各疾病的诊疗规范；在对免疫系统疾病的概念、病因与发病机制、临床表现、诊断与鉴别诊断及治疗的描写中，注重诊疗思维的培养；每一章节末尾的诊疗流程图都是编者斟字酌句，潜心提炼的精华之笔，为广大儿科医生和儿童免疫科医生提供详尽、全面的参考。
本套丛书已经成为各级儿科从业人员日常学习和参考的案头工具书，为儿科学科发展起到积极的促进作用。
全书43万字，在上一版的基础上修订30%以上，共六章，包括儿童免疫学总论、原发性免疫缺陷病、继发性免疫缺陷病、儿童过敏性疾病、儿童风湿性疾病、免疫功能异常与疫苗接种。全书文字精炼、表达流畅、脉络清晰、内容经典、重点突出、理念先进，并有大量诊治流程图，为读者提供分析思路，是一本具备先进性、科学性和实用性的专业工具书。
赵晓东：中华医学会儿科学分会免疫学组前任组长
宋红梅：中华医学会儿科学分会免疫学组组长
第一节免疫系统/1
第二节免疫应答/2
第三节免疫应答失调与疾病/4
|第二章|原发性免疫缺陷病/9
第一节原发性免疫缺陷病概述/9
第二节原发性免疫缺陷病分类/14
第三节免疫功能评估/90
第四节原发性免疫缺陷疾病临床表现及早期识别/97
第五节重症联合免疫缺陷病/102
第六节湿疹、血小板减少伴免疫缺陷综合征/112
第七节DiGeorge综合征/118
第八节高IgE综合征/122
第九节X-连锁无丙种球蛋白血症/131
儿童免疫学涵盖的原发性免疫缺陷病（PID）、儿童过敏性疾病和儿童风湿性疾病，免疫系统功能异常是这几类疾病最重要的发病机制。儿童免疫系统发育特征决定了儿童时期的这几类疾病也具有鲜明的、不同于成人的疾病特点。可见，儿童免疫学涵盖的上述三类经典疾病其实同宗同源，具有深厚的内在联系。还值得强调的是，儿童免疫性疾病许多临床表型也与儿科学各亚学科（专业）密切相关。因此，儿科免疫性疾病的诊疗过程必须采取学科交叉的方法。
近10 年是儿童免疫学进入爆发式发展时期，免疫学发展速度非常迅猛，大量的基础和相关转化研究成果如雨后春笋般涌现。随着高通量测序技术的广泛应用，原发性免疫缺陷病致病基因增长到目前的400 多个，除经典免疫分子外，表观遗传、核酸和蛋白质稳态维持等一系列相关基因变异导致的原发性免疫缺陷病不断被发现。诸多免疫通路的运行规律以原发性免疫缺陷病病例为研究对象得以破解。众多小分子 / 大分子药物依托免疫靶点得以发明并应用于临床，多种原发性免疫缺陷病的基因治疗完成了临床试验。同样，儿童风湿病 / 过敏性疾病的理论研究和临床实践也在飞速发展，人们对感染过程的深入解析，阐明了感染本身的转归规律，也部分阐明了肿瘤发生的多种机制。
Shipping Overview:
• Shipping: Standard Domestic Shipping within the United States charges USD 4.99. Standard International Shipping from United Kingdom and Germany to the United States charges 14.99.
• Order Processing: Please allow 1-2 business days for order processing and preparation before shipment.
• Domestic Shipping: Orders within the U.S. are shipped via USPS or FedEx, depending on the origin of the product. The average transit time is 3-7 business days.
• International Shipping: Currently, we only ship within the USA.
• Tracking Information: Every order is trackable. You will receive a tracking number once your order has been shipped. Products may be shipped from various global fulfillment centers.
Shipping Delays:
Please note that shipping times may vary due to factors beyond our control, such as weather conditions, natural disasters, or peak holiday periods. While we strive to ensure timely delivery, the exact arrival time cannot be guaranteed and is managed by the shipping carrier.
Shipping Options:
-
Standard Delivery: Most orders are shipped within 3-7 business days. Larger items may utilize LTL shipping for safe handling.
-
Handling Time: We handle shipments on business days (Monday - Friday), with a preparation time of 1-2 days.
-
Additional Charges: Some items require additional shipping charges due to their size, weight, or special handling. These charges are specified on the product pages and are not eligible for shipping discounts.
-
Exclusions: Gift cards, packaging, taxes, and prior purchases do not count toward the minimum purchase requirement for free shipping. This offer is valid only for shipments to U.S. addresses, including Puerto Rico.
Delivery Details:
-
Estimates: Standard shipping within the US typically takes 3-7 business days. These are estimates and not guarantees.
-
Shipping Restrictions: We ship to all 50 states, Washington, DC, U.S. territories, and APO/FPO/DPO addresses. Shipping options vary based on the delivery address.
-
Remote Areas: Shipments to remote areas may incur additional charges or require pickup from a nearby shipping partner’s location.
Shipping Confirmation:
You will receive a shipping confirmation email with a tracking number as soon as your order is dispatched. If you do not receive this email immediately, please be assured that your items will arrive within the estimated delivery window provided at checkout.
Order Modifications:
If you need to cancel or modify your order, please contact our customer support immediately.
Issues with Delivery:
If your order shows as delivered but you have not received it, please contact the shipping carrier directly to resolve the issue. For persistent problems, contact our customer service at cs@everymarket.com.
Customer Support:
Our team is available 24/7 to assist you with any questions or concerns regarding your order. We are committed to ensuring a smooth shopping experience.
Return & Refund Policy Overview
Please review our return and refund policies below to ensure a smooth transaction process.
Return Policy
-
Duration: You have 30 days from receiving your item to initiate a return.
-
Condition: Items must be unworn, unwashed, with original tags and packaging intact.
-
Shipping Costs: Customers are responsible for return shipping costs.
-
Packaging: Ensure returned items are well-packaged to avoid damage during transit.
-
Tracking: Use a trackable and insured shipping method as we are not liable for items lost or damaged on return.
-
Initiating a Return: Contact us at cs@everymarket.com to start your return. We will provide a return shipping label and instructions upon approval. Returns without prior approval will not be accepted.
How to Return
-
Method: Returns must be sent back by mail to the address provided in the return instructions.
Return Label
-
Defective Products: Return labels are provided for defective items.
-
Non-Defective Returns: Customers are responsible for obtaining their return shipping label.
Product Conditions for Return
-
Eligible Products: Returns are only accepted for items in new condition.
Nonreturnable Items
Certain items are not eligible for return:
-
Electronic devices after 30 days (e.g., computers, laptops, Kindles)
-
Gift cards, prepaid game cards
-
Perishable goods, live insects, some jewelry, some health and personal care items
-
Customized or personalized products
-
Items with special shipping restrictions
Refund Policy
-
Window: Eligible products may be returned within 30 days of delivery for a refund.
-
Refund Method: Refunds are processed to the original payment method or as store credit for items purchased with gift cards.
-
Processing Time: Refunds are processed within 3-5 business days after we receive the return; please allow additional time for shipping and bank processing.
Claims
Inspect your order upon arrival and report any defects, damages, or incorrect items immediately to allow us to address the issue. For claims, contact our support team with details of the issue.
Exchange Policy
For the quickest service, return your original item and place a new order for the desired product once your return is accepted.
Return Address
EveryMarket Customer Service 2101 E Terra Ln, O'Fallon, MO 63366
Customer Support
Available 24/7 for any questions or assistance needed:
-
Phone: +1 636-312-5925
-
Email: cs@everymarket.com
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