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临床血液学图谱 (原书第6版)
$72.74
体液细胞形态在各种肿瘤诊断中意义非凡,它有助于疾病的早发现、早诊断、早治疗,改善疾病预后,节约医疗费用。
本书引进自 ELSEVIER 出版社,是一部全面的形态学图谱,为全新第 6 版,在第 5 版的基础上优化和增加了新内容,同时还按照全新的 WHO 诊断标准修订了部分分类及知识点。全书共五篇24 章,内容涉及外周血涂片的制片及染色、血细胞发育的特征、各系血细胞不同阶段的形态学特征等,同时结合电镜与光镜图片的对比及示意图,便于初学者理解和记忆,包括红细胞的异常形态和特殊结构用于疾病的诊断,白细胞的异常形态、白细胞过度增殖及异常与血液疾病的关系,特殊细胞的呈现,集落刺激因子使用后的形态学变化,新生儿血液的形态学特征和体液细胞形态学概略等。本书涵盖了血液细胞形态学及体液细胞形态学,可作为形态学入门及广大形态学爱好者的实用参考书。
原著者:Jacqueline H. Carr,美国印第安纳州印第安纳波利斯Clarian Health病理学和临床实验室主任。
主译:顾大勇,深圳大学附属医院检验科负责人,深圳市科技领军人才。中华预防医学会卫生检验专业委员会空气微生物学组委员会委员,《中华检验医学杂志》编辑委员会青年委员等。
李延武,深圳市第二人民医院检验科副主任,广东省医疗行业协会医学检验管理分会委员。
杜新,主任医师,博士研究生导师。深圳市第二人民医院血液内科主任及大内科主任,深圳市血液病研究所所长。
篇 总论第 1 章 外周血涂片检查介绍一、血涂片制备 二、外周血涂片检查三、总结 第二篇 造血第 2 章 血细胞的生成 第 3 章 红细胞的发育与成熟 一、原红细胞 二、早幼红细胞 三、中幼红细胞 四、晚幼红细胞 五、多色素性红细胞 / 网织红细胞 六、红细胞 第 4 章 巨核细胞的发育与成熟 一、原巨核细胞 二、幼巨核细胞 三、巨核细胞 四、血小板 第 5 章 中性粒细胞的发育与成熟 一、原粒细胞 二、早幼粒细胞 三、中性中幼粒细胞四、中性晚幼粒细胞 五、中性杆状核粒细胞 六、中性分叶核粒细胞 第 6 章 嗜酸性粒细胞的发育与成熟 一、嗜酸性中幼粒细胞 二、嗜酸性晚幼粒细胞三、嗜酸性杆状核粒细胞 四、嗜酸性粒细胞 第 7 章 嗜碱性粒细胞的发育与成熟 嗜碱性粒细胞第 8 章 单核细胞的发育与成熟一、原单核细胞 二、幼单核细胞 三、单核细胞 四、巨噬细胞 第 9 章 淋巴细胞的发育与成熟一、淋巴母细胞二、幼淋巴细胞三、淋巴细胞四、浆细胞 第三篇 红细胞第 10 章 红细胞大小与颜色的变化一、大小的变化 二、红细胞大小不均三、红细胞颜色的变化第 11 章 红细胞形态和分布的变化一、异形红细胞 二、分布 第 12 章 红细胞的内含物 一、豪 - 乔小体 二、嗜碱性点彩 三、帕彭海姆小体 / 铁质颗粒 四、卡伯特环 五、活体染色的包涵物 / 新亚甲蓝染色第 13 章 疾病对红细胞的影响 一、小细胞低色素性贫血 二、正色素性大红细胞 三、正细胞正色素性贫血 第四篇 白细胞第 14 章 白细胞细胞核与细胞质的变化 一、中性粒细胞核分叶不良 二、中性粒细胞核分叶过多 三、中性粒细胞空泡现象四、杜勒小体五、蓝绿色包涵体 六、中毒颗粒 七、中性粒细胞颗粒减少或缺失 八、反应性淋巴细胞第 15 章 急性髓系白血病 一、急性髓系白血病微分化型 二、急性髓系白血病伴不成熟型三、急性髓系白血病伴成熟型 四、急性早幼粒细胞白血病伴 PML-RARA, FAB M3 型 五、急性早幼粒细胞白血病伴 PML-RARA:微颗粒型(少颗粒型),FAB M3六、急性粒单核细胞白血病 七、急性髓系白血病伴 inv(16)(p13.1; q22)或 t(16; 16)(p13.1; q22); CBFB-MYH11 八、急性单核细胞白血病 九、纯红系细胞白血病 十、急性巨核细胞白血病 十一、急性嗜碱性粒细胞白血病 第 16 章 前体淋巴细胞肿瘤 一、急性淋巴细胞白血病,小原始细胞 二、急性淋巴细胞白血病,大原始细胞 第 17 章 骨髓增殖性肿瘤 一、慢性髓细胞性白血病,BCR-ABL1 二、白细胞碱性磷酸酶染色 三、真性红细胞增多症 四、原发性血小板增多症五、原发性骨髓纤维化第 18 章 骨髓增生异常综合征 一、红系病态造血 二、粒系病态造血 三、巨核系病态造血 第 19 章 淋巴细胞增殖性疾病 一、慢性淋巴细胞白血病 二、幼淋巴细胞白血病 三、毛细胞白血病 四、浆细胞骨髓瘤 五、伯基特白血病 / 淋巴瘤 六、淋巴瘤 第 20 章 造血细胞因子使用后的形态学改变第五篇 其他第 21 章 微生物 一、疟原虫二、巴贝虫 三、罗阿丝虫 四、锥虫 五、真菌 六、细菌 第 22 章 其他细胞 一、系统性疾病的血液学表现 二、Chédiak-Higashi 综合征 三、骨髓中可见的其他细胞 四、外周血涂片杂质 第 23 章 新生儿正常外周血细胞形态 第 24 章 体液 一、脑脊液常见细胞 二、脑脊液偶见细胞 三、中枢神经系统出血后脑脊液中的细胞变化 四、脑脊液中微生物 五、浆膜腔(胸腔、心包腔和腹腔)积液细胞 六、间皮细胞 七、多核间皮细胞 八、浆膜腔积液恶性细胞九、滑膜腔积液中的结晶 十、体液中的其他物质 附录 A 词汇表附录 B 血液学常用缩略语
1590 年,荷兰的 Jannsen 父子发明了光学显微镜,这使得观察细胞结构及血液细胞构成变为可能。1665 年,Hook 用自制显微镜发现并命名了细胞,即“cell”。此后,随着染液的发现和使用,细胞形态学逐步有了雏形。随着科学技术的不断发展,细胞形态学逐步成长为众多学科的一个分支,不仅有了细胞形态学,还有了病理组织学、免疫组织化学、细胞免疫化学、分子细胞遗传学和细胞生物学等相关学科。现如今,尽管各式高精密仪器设备在临床的应用范围越来越广,但其依然不能完全替代人工审核,其中,细胞形态学检测仍是人工智能不能完全替代的方面。细胞的多形性、多态性及环境等影响因素的多变性,导致了细胞形态千差万别。在临床诊断过程中,细胞形态学始终站在前线,是临床医生的“眼睛”,也是疾病综合诊断的前哨。细胞形态学检测的及时、快速与经济性,能够有力地支撑和辅助疾病的诊断。目前,人们越来越重视细胞形态学的发展,国内每年都会举办不同规模和级别的细胞形态学大赛,究其原因,就是人们意识到细胞形态学的普及非常重要,而基层医院这一环节非常薄弱,由于对细胞形态学的认识不足,容易导致漏诊、误诊等问题。因此,大力推广细胞形态学技术、提高检验医生的素质,成为医疗质量提升的重要保障。我们从众多图谱中精挑细选了这部 Clinical Hematology Atlas, 6e,深入浅出地描述了血细胞发生及发展的规律、疾病与血细胞形态变化的关系。让人惊喜的是,本书的血细胞基础知识部分,光镜图片都配有电镜图片及示意图,这对初学者而言帮助极大,更容易理解光镜下血细胞形态和结构变化的本质改变、超微结构中细胞器对应的血细胞形态特征等。此外,本书不但介绍了血液细胞形态学,还描述了体液细胞形态学,而目前国内的大多数形态学图谱类著作中这两者基本都是分开的。作为形态学从业者,既要了解血细胞形态学,也要了解体液细胞形态学,这也是我们选择翻译本书的初衷。希望本书能够方便大家学习和使用,成为临床检验医生的案头参考书。本书的翻译团队非常专业和敬业,尽管有新冠肺炎疫情的干扰,但译者们竭尽全力,进行了多次修改和校对,终得以与读者见面,非常值得期待。深圳市第二人民医院 徐勇
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